Computational Molecular Biology Mid - I, September - 2014

1.The term Genomics was given by ______________
  • J.C.R Licklider
  • Leonard Kleinorock
  • Thomas H Roderick
  • Tim Berner lee.
Answer: C
2.What is the main stabilizing force in the secondary structure of proteins
  • Sulphide bonds
  • hydrogen bonds
  • amide bonds
  • peptide bonds
Answer: B
3.Dynamics of biochemical networks can be represented by an elegant system of differential equation is known as
  • Riccati system
  • S-system
  • R-system
  • Generalized mass action
Answer: B
4.Which of these can be used to analyze the whole genome at once?
  • Expressed sequence tags (ESTs)
  • DNA microarrays
  • 454 sequencing
  • TIGR
Answer: B
5.Micro array Technology is used for __________experiments.
  • DNA sequencing
  • DNA hybridization
  • DNA fingerprinting
  • DNA polymerization
Answer: C
6.ORF scanning
  • Is used to find exons
  • Is used to find intergenic sequences
  • Is used to find gene homologies
  • Is used to find protein-coding genes
Answer: D
7.In 19987, organization (s) established in the field of genomics and bioinformatics
  • Celera Genomics
  • Swiss institute of Bio-informatics
  • both of these
  • none of these
Answer: C
8.Which among the following is the software tool for peptide mass mapping and sequencing
  • Find Mod
  • SEAQUEST
  • SWISS-2Dpage
  • Peptide search
Answer: D
9.EST represents
  • Promoter
  • operator
  • protein coding gene
  • signaling gene
Answer: C
10.VNTR means ___________________________
  • Variable number of tandem repeats
  • variable number of thymine repeats
  • various number of Tandem Repeats
  • none of the above
Answer: A
11.Homology gene predication is also known as _______________
Answer: Extrinsic method
12.Amino acid substitutions that do not significantly change the function of protein are called as ___________________
Answer: PAM
13.The arrays often use short sequences (~25 base pairs in length) that are unique to a gene, rather than the entire gene sequence. These short sequences are called______________ and they are derived from cDNA molecules.
Answer: EST
14.____________analysis has allowed scientists to view the expression of specific genes in a cell.
Answer: Microaaray
15.Study of the collection of proteins produced in a particular cell_______________
Answer: Proteomics
16.“3-D structure of the main chain of protein is determined by the dihedral angles ψ and φ”. This concept was proposed by ________________
Answer: Levinthal
17._____________electrophoresis is used to study pka and pi values of proteins.
Answer: 2D
18.Chow fasman method and GOR method are used to predict the____________ structures of proteins
Answer: Secondary
19.PROWL provide information about ______________ structure
Answer: Primary
20.The S-system formulation is criticized for it manner of ___________________
Answer: Hapoloid geno type